Agustín Ibáñez
Allison B. Reiss
Nilton Custodio
Federica Agosta- 1Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago de Chile, Chile
- 2Cognitive Neuroscience Center (CNC), Universidad de San Andrés and CONICET, Buenos Aires, Argentina
- 3Global Brain Health Institute (GBHI), University of California San Francisco (UCSF), San Francisco, CA, United States
- 4Trinity College Dublin (TCD), Dublin, Ireland
- 5Department of Medicine and Biomedical Research Institute, NYU Grossman Long Island School of Medicine, Mineola, NY, United States
- 6Department of Neurology, Instituto Peruano de Neurociencias, Lima, Peru
- 7Unit of Diagnosis of Cognitive Impairment and Dementia Prevention, Instituto Peruano de Neurociencias, Lima, Peru
- 8Vita-Salute San Raffaele University Milan, Milan, Italy
Editorial on the Research Topic
Insights in Alzheimer's disease and related dementias: 2022
Introduction
Dementia impacts over 55 million individuals globally, creating a pressing public health concern characterized by cognitive and functional decline beyond typical aging. As highlighted by the World Alzheimer Report (Alzheimer's Disease International, 2022) and the World Health Organization (2022), Alzheimer's disease (AD) and related dementia (ADRD) are the principal cause of disability, dependence, and death among the elderly. Its repercussions, both personally and socially, vary in magnitude, often reflecting the inequality gradients of the respective nations. Today's research in aging, dementia, and other brain diseases is moving away from one-size-fits-all models to embrace multifaceted, heterogeneity-aware, and diversity-driven paradigms (Alladi and Hachinski, 2018; Parra et al., 2018, 2021, 2022; Dehghani et al., 2021; Deco et al., 2022; Frisoni et al., 2022; Ibanez, 2022; Moguilner et al., 2022; Ibanez and Zimmer, 2023; Ibanez et al., 2023; Maito et al., 2023; Santamaria-Garcia et al., 2023). This dynamic evolution in dementia studies is pioneering new interdisciplinary connections, spanning various methods, scales, populations, and regions. It dives into genetic diversity, protein aggregation patterns, synaptic activities, disparities across multiple fronts, advanced biomarkers, and the interplay of environmental triggers with physiological stress mechanisms. Moreover, a trend toward non-generalized samples and unique research designs in neuroscience has become evident. Years of research have enhanced our understanding of AD's underlying mechanisms. Technological and diagnostic advancements have paved the way for therapeutic innovations, as evidenced by the recent FDA approval of drugs such as Aduhelm and Lecanemab, marking progress in the field. While research in ADRD has significantly broadened over the years, these advancements have led to improved patient outcomes. However, challenges persist, such as complexities related to heterogeneity in disease presentation, the lack of early detection biomarkers, and the absence of massive development of disease-modifying therapies.
As we journey into the third decade of the twenty first Century, remarkable strides have been made in Alzheimer's disease and related dementia. Frontiers has curated a series of Research Topics to spotlight these advancements in Aging Neuroscience. This special edition, titled “Insights in Alzheimer's disease and related dementias,” offers a concise overview of selected studies to enlighten and guide the research community.
There has been a growing interest in different factors impacting cognitive function, dementia, and Alzheimer's disease (AD). Costa-Laparra et al. delved into the relationship between specific genetic factors, such as the APOE ε4 allele and G206D-PSEN1 mutation, and mitochondrial abnormalities in AD. Their study demonstrated that these genetic variations could lead to mitochondrial fragmentation and an increased propensity for oxidative stress-induced cell death, potentially contributing to AD and neurodegeneration. Yang et al. explored the impact of hearing aids on cognitive function in middle-aged and older adults with hearing loss, including those with AD, dementia, and depressive symptoms. Their meta-analysis revealed that for those with AD or dementia, hearing aids did not significantly enhance cognitive function. Thus, the efficacy of these aids in non-demented subjects remains uncertain.
In a diverse population, Chen et al. devised a predictive model for cognitive impairment in elderly illiterate Chinese women (n = 1864), determining that age, daily living activities, and waist-to-height ratio were critical predictors. Meanwhile, Hwangbo et al. drawing longitudinal data from South Korea (n = 794,448), identified physical inactivity, diabetes, and hypertension as the top modifiable risk factors for dementia, emphasizing the importance of lifestyle modifications for prevention. Lastly, Balzamino et al. used a Reeler murine model, deficient in the Reelin protein, to show parallels between pathological hallmarks of AD and ocular degeneration, suggesting potential shared pathways in neurodegenerative diseases and age-related macular degeneration.
Collectively, these studies underscore the multifaceted nature of cognitive decline and dementia, hinting at diverse intervention points for prevention and treatment. This Research Topic showcases handpicked studies from Alzheimer's disease and related dementia research. Our aspiration is that these insights not only spotlight past advancements but also illuminate the upcoming challenges in the domain.
Author contributions
AI: Conceptualization, Funding acquisition, Writing—original draft, Writing—review and editing. AR: Writing—original draft, Writing—review and editing. NC: Writing—original draft, Writing—review and editing. FA: Writing—original draft.
Funding
AI was partially supported by grants from ANID/FONDECYT Regular (1210195, 1210176, and 1220995); ANID/FONDAP/15150012; ANID/PIA/ANILLOS ACT210096; FONDEF ID20I10152; ANID/FONDAP 15150012; and the Multi-Partner Consortium to Expand Dementia Research in Latin America [ReDLat, supported by Fogarty International Center (FIC) and National Institutes of Health, National Institutes of Aging (R01 AG057234, R01 AG075775, R01 AG21051, and CARDS-NIH), Alzheimer's Association (SG-20-725707), Rainwater Charitable foundation–Tau Consortium, the Bluefield Project to Cure Frontotemporal Dementia, and Global Brain Health]. AR was supported by the Alzheimer's Foundation of America (Award AWD00004772) and The Herb and Evelyn Abrams Family Amyloid Research Fund.
Conflict of interest
FA is Associate Editor of NeuroImage: Clinical, has received speaker honoraria from Biogen Idec, Italfarmaco, Roche, Zambonand Ely Lilli, and receives or has received research supports from the Italian Ministry of Health, the Italian Ministry of University and Research, AriSLA (Fondazione Italiana di Ricerca per la SLA), the European Research Council, the EU Joint Programme–Neurodegenerative Disease Research (JPND), and Foundation Research on Alzheimer Disease (France).
The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.
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References
Alladi, S., and Hachinski, V. (2018). World dementia: one approach does not fit all. Neurology 91, 264–270. doi: 10.1212/WNL.0000000000005941
Alzheimer's Disease International (2022). World Alzheimer Report 2022. London: Alzheimer's Disease International.
Deco, G., Sanz Perl, Y., Bocaccio, H., Tagliazucchi, E., and Kringelbach, M. L. (2022). The INSIDEOUT framework provides precise signatures of the balance of intrinsic and extrinsic dynamics in brain states. Commun. Biol. 5, 572. doi: 10.1038/s42003-022-03505-7
Dehghani, N., Bras, J., and Guerreiro, R. (2021). How understudied populations have contributed to our understanding of Alzheimer's disease genetics. Brain 144, 1067–1081. doi: 10.1093/brain/awab028
Frisoni, G. B., Altomare, D., Thal, D. R., Ribaldi, F., van der Kant, R., Ossenkoppele, R., et al. (2022). The probabilistic model of Alzheimer disease: the amyloid hypothesis revised. Nat. Rev. Neurosci. 23, 53–66. doi: 10.1038/s41583-021-00533-w
Ibanez, A. (2022). The mind's golden cage and cognition in the wild. Trends Cogn. Sci. 26, 1031–1034. doi: 10.1016/j.tics.2022.07.008
Ibanez, A., Legaz, A., and Ruiz-Adame, M. (2023). Addressing the gaps between socioeconomic disparities and biological models of dementia. Brain 146, 3561–3564. doi: 10.1093/brain/awad236
Ibanez, A., and Zimmer, E. (2023). Time to synergize mental health with brain health. Nat. Mental Health 1 441–443. doi: 10.1038/s44220-023-00086-0
Maito, M. A., Santamaría-García, H., Moguilner, S., Possin, K. L., Godoy, M. E., Avila-Funes, J. A., et al. (2023). Classification of Alzheimer's disease and frontotemporal dementia using routine clinical and cognitive measures across multicentric underrepresented samples: a cross sectional observational study. The Lancet Reg. Health Am. 17, 387. doi: 10.1016/j.lana.2022.100387
Moguilner, S., Birba, A., Fittipaldi, S., Gonzalez-Campo, C., Tagliazucchi, E., Reyes, P., et al. (2022). Multi-feature computational framework for combined signatures of dementia in underrepresented settings. J. Neural. Eng. 19, 4. doi: 10.1088/1741-2552/ac87d0
Parra, M. A., Baez, S., Allegri, R., Nitrini, R., Lopera, F., Slachevsky, A., et al. (2018). Dementia in Latin America: assessing the present and envisioning the future. Neurology 90, 222–231. doi: 10.1212/WNL.0000000000004897
Parra, M. A., Baez, S., Sedeño, L., Gonzalez Campo, C., Santamaría-García, H., Aprahamian, I., et al. (2021). Dementia in Latin America: paving the way toward a regional action plan. Alzheimers Dement. 17, 295–313. doi: 10.1002/alz.12202
Parra, M. A., Orellana, P., Leon, T., Victoria, C. G., Henriquez, F., Gomez, R., et al. (2022). Biomarkers for dementia in Latin American countries: gaps and opportunities. Alzheimers Dement. 19, 721–735. doi: 10.1002/alz.12757
Santamaria-Garcia, H., Sainz-Ballesteros, A., Hernandez, H., Moguilner, S., Maito, M., Ochoa-Rosales, C., et al. (2023). Factors associated with healthy aging in Latin American populations. Nat Med. 10, 1–11. doi: 10.1038/s41591-023-02495-1
Keywords: Alzheimer's disease (AD), dementia, brain health, neurodegeneration, animal studies, human studies
Citation: Ibáñez A, Reiss AB, Custodio N and Agosta F (2023) Editorial: Insights in Alzheimer's disease and related dementias: 2022. Front. Aging Neurosci. 15:1279870. doi: 10.3389/fnagi.2023.1279870
Received: 18 August 2023; Accepted: 12 September 2023;
Published: 22 September 2023.
Edited by:
Xiaobo Mao, Johns Hopkins University, United StatesReviewed by:
Xiaodi Zhang, Johns Hopkins Medicine, United StatesRamhari Kumbhar, Johns Hopkins Medicine, United States
Ning Wang, Johns Hopkins University, United States
Copyright © 2023 Ibáñez, Reiss, Custodio and Agosta. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Agustín Ibáñez, YWd1c3Rpbi5pYmFuZXomI3gwMDA0MDtnYmhpLm9yZw==