AUTHOR=Du Hao , Xia Jian , Huang Lei , Zheng Lan , Gu Wenping , Yi Fang TITLE=Relationship between insulin-like growth factor-1 and cerebral small vessel disease and its mechanisms: advances in the field JOURNAL=Frontiers in Aging Neuroscience VOLUME=15 YEAR=2023 URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2023.1190869 DOI=10.3389/fnagi.2023.1190869 ISSN=1663-4365 ABSTRACT=

Insulin-like growth factor-1 (IGF-1) is an active polypeptide protein that closely resembles the structural sequence of insulin and is involved in a variety of metabolic processes in the body. Decreased IGF-1 circulation levels are associated with an increased risk of stroke and a poorer prognosis, but the relationship with cerebral small vessel disease (cSVD) is unclear. Some studies found that the level of IGF-1 in patients with cSVD was significantly reduced, but the clinical significance and underlying mechanisms are unknown. This article reviews the correlation between IGF-1 and cerebrovascular disease and explores the potential relationship and mechanism between IGF-1 and cSVD.