AUTHOR=Ding Zhao , Fan Xiaodi , Zhang Yehao , Yao Mingjiang , Wang Guangrui , Dong Yilei , Liu Jianxun , Song Wenting 

TITLE=The glymphatic system: a new perspective on brain diseases

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=15

YEAR=2023

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2023.1179988

DOI=10.3389/fnagi.2023.1179988

ISSN=1663-4365

ABSTRACT=<p>The glymphatic system is a brain-wide perivascular pathway driven by aquaporin-4 on the endfeet of astrocytes, which can deliver nutrients and active substances to the brain parenchyma through periarterial cerebrospinal fluid (CSF) influx pathway and remove metabolic wastes through perivenous clearance routes. This paper summarizes the composition, overall fluid flow, solute transport, related diseases, affecting factors, and preclinical research methods of the glymphatic system. In doing so, we aim to provide direction and reference for more relevant researchers in the future.</p>