AUTHOR=Yan Chengjie , Zheng Yu , Zhang Xintong , Gong Chen , Wen Shibin , Zhu Yonggang , Jiang Yujuan , Li Xipeng , Fu Gaoyong , Pan Huaping , Teng Meiling , Xia Lingfeng , Li Jian , Qian Kun , Lu Xiao 

TITLE=Development and validation of a nomogram model for predicting unfavorable functional outcomes in ischemic stroke patients after acute phase

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=15

YEAR=2023

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2023.1161016

DOI=10.3389/fnagi.2023.1161016

ISSN=1663-4365

ABSTRACT=<sec><title>Introduction</title><p>Prediction of post-stroke functional outcome is important for personalized rehabilitation treatment, we aimed to develop an effective nomogram for predicting long-term unfavorable functional outcomes in ischemic stroke patients after acute phase.</p></sec><sec><title>Methods</title><p>We retrospectively analyzed clinical data, rehabilitation data, and longitudinal follow-up data from ischemic stroke patients who underwent early rehabilitation at multiple centers in China. An unfavorable functional outcome was defined as a modified Rankin Scale (mRS) score of 3–6 at 90 days after onset. Patients were randomly allocated to either a training or test cohort in a ratio of 4:1. Univariate and multivariate logistic regression analyses were used to identify the predictors for the development of a predictive nomogram. The area under the receiver operating characteristic curve (AUC) was used to evaluate predictive ability in both the training and test cohorts.</p></sec><sec><title>Results</title><p>A total of 856 patients (training cohort: <italic>n</italic> = 684; test cohort: <italic>n</italic> = 172) were included in this study. Among them, 518 patients experienced unfavorable outcomes 90 days after ischemic stroke. Trial of ORG 10172 in Acute Stroke Treatment classification (<italic>p</italic> = 0.024), antihypertensive agents use [odds ratio (OR) = 1.86; <italic>p</italic> = 0.041], 15-day Barthel Index score (OR = 0.930; <italic>p</italic> &lt; 0.001) and 15-day mRS score (OR = 13.494; <italic>p</italic> &lt; 0.001) were selected as predictors for the unfavorable outcome nomogram. The nomogram model showed good predictive performance in both the training (AUC = 0.950) and test cohorts (AUC = 0.942).</p></sec><sec><title>Conclusion</title><p>The constructed nomogram model could be a practical tool for predicting unfavorable functional outcomes in ischemic stroke patients underwent early rehabilitation after acute phase.</p></sec>