AUTHOR=Carbonell Abigail U. , Freire-Cobo Carmen , Deyneko Ilana V. , Dobariya Saunil , Erdjument-Bromage Hediye , Clipperton-Allen Amy E. , Page Damon T. , Neubert Thomas A. , Jordan Bryen A. TITLE=Comparing synaptic proteomes across five mouse models for autism reveals converging molecular similarities including deficits in oxidative phosphorylation and Rho GTPase signaling JOURNAL=Frontiers in Aging Neuroscience VOLUME=15 YEAR=2023 URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2023.1152562 DOI=10.3389/fnagi.2023.1152562 ISSN=1663-4365 ABSTRACT=
Specific and effective treatments for autism spectrum disorder (ASD) are lacking due to a poor understanding of disease mechanisms. Here we test the idea that similarities between diverse ASD mouse models are caused by deficits in common molecular pathways at neuronal synapses. To do this, we leverage the availability of multiple genetic models of ASD that exhibit shared synaptic and behavioral deficits and use quantitative mass spectrometry with isobaric tandem mass tagging (TMT) to compare their hippocampal synaptic proteomes. Comparative analyses of mouse models for Fragile X syndrome (