AUTHOR=Huang Juan , Huang Nanqu , Mao Qianhua , Shi Jingshan , Qiu Yu 

TITLE=Natural bioactive compounds in Alzheimer's disease: From the perspective of type 3 diabetes mellitus

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=15

YEAR=2023

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2023.1130253

DOI=10.3389/fnagi.2023.1130253

ISSN=1663-4365

ABSTRACT=<p>There is a close relationship between Alzheimer's disease (AD) and diabetes mellitus (DM), and the link between the two is often referred to as type 3 diabetes mellitus (T3DM). Many natural bioactive compounds have shown the potential to treat AD and diabetes. We mainly review the polyphenols represented by resveratrol (RES) and proanthocyanidins (PCs) and alkaloids represented by berberine (BBR) and <italic>Dendrobium nobile</italic> Lindl. alkaloids (DNLA) from the perspective of T3DM to review the neuroprotective effects and molecular mechanisms of natural compounds in AD.</p>