Skip to main content

CORRECTION article

Front. Aging Neurosci. , 27 February 2023

Sec. Alzheimer's Disease and Related Dementias

Volume 15 - 2023 | https://doi.org/10.3389/fnagi.2023.1073356

Corrigendum: PMCA-based detection of prions in the olfactory mucosa of patients with sporadic Creutzfeldt–Jakob disease

This article is a correction to:

  1. PMCA-Based Detection of Prions in the Olfactory Mucosa of Patients With Sporadic Creutzfeldt–Jakob Disease

    1. Read original article
\nFederico Angelo CazzanigaFederico Angelo Cazzaniga1Edoardo BistaffaEdoardo Bistaffa1Chiara Maria Giulia De Luca,Chiara Maria Giulia De Luca1,2Sara Maria PortaleoneSara Maria Portaleone3Marcella CataniaMarcella Catania1Veronica RedaelliVeronica Redaelli1Irene TramacereIrene Tramacere4Giuseppe BufanoGiuseppe Bufano1Martina Rossi&#x;Martina Rossi2†Paola CaroppoPaola Caroppo1Anna Rita GiovagnoliAnna Rita Giovagnoli1Pietro TiraboschiPietro Tiraboschi1Giuseppe Di FedeGiuseppe Di Fede1Roberto EleopraRoberto Eleopra5Grazia DevigiliGrazia Devigili5Antonio Emanuele EliaAntonio Emanuele Elia5Roberto CiliaRoberto Cilia5Michele FioriniMichele Fiorini6Matilde BongianniMatilde Bongianni6Giulia Salzano&#x;Giulia Salzano2†Luigi CelauroLuigi Celauro2Federico Giuseppe QuartaFederico Giuseppe Quarta3Angela MammanaAngela Mammana7Giuseppe LegnameGiuseppe Legname2Fabrizio TagliaviniFabrizio Tagliavini8Piero Parchi,Piero Parchi7,9Gianluigi ZanussoGianluigi Zanusso6Giorgio GiacconeGiorgio Giaccone1Fabio Moda Fabio Moda1*
  • 1Unit of Neurology 5 and Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
  • 2Department of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Trieste, Italy
  • 3Department of Health Sciences, Otolaryngology Unit, ASST Santi Paolo e Carlo Hospital, Università degli Studi di Milano, Milan, Italy
  • 4Department of Research and Clinical Development, Scientific Directorate, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
  • 5Unit of Neurology 1 – Parkinson's and Movement Disorders Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
  • 6Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy
  • 7IRCCS, Istituto delle Scienze Neurologiche di Bologna (ISNB), Bologna, Italy
  • 8Scientific Directorate, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
  • 9Department of Diagnostic Experimental and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy

A corrigendum on
PMCA-based detection of prions in the olfactory mucosa of patients with sporadic Creutzfeldt–Jakob disease

by Cazzaniga, F. A., Bistaffa, E., De Luca, C. M. G., Portaleone, S. M., Catania, M., Redaelli, V., Tramacere, I., Bufano, G., Rossi, M., Caroppo, P., Giovagnoli, A. R., Tiraboschi, P., Di Fede, G., Eleopra, R., Devigili, G., Elia, A. E., Cilia, R., Fiorini, M., Bongianni, M., Salzano, G., Celauro, L., Quarta, F. G., Mammana, A., Legname, G., Tagliavini, F., Parchi, P., Zanusso, G., Giaccone, G., and Moda, F. (2022). Front. Aging Neurosci. 14:848991. doi: 10.3389/fnagi.2022.848991

In the published article, there was an error in Figure 5 as published. In particular, the Western blot showed in the original Figure 5D related to the 1st round of PMCA of patient 19 (19_BH) was mistakenly selected and has now been replaced with the correct one. The corrected Figure 5D and its caption appear below.

FIGURE 5
www.frontiersin.org

Figure 5. Quantitative PMCA (qPMCA) for estimating PrPres concentration in OM samples of sCJD patients. (A) Serial dilutions of recombinant full-length human PrP (recHuPrP23−231) were used to estimate prion concentration in the brain of sCJD patients. (B) Serial dilutions of sCJD brain homogenates subjected to PK and PNGase treatments before Wb analysis. Quantitative PMCA to estimate PrPres concentration in OM of (C) MM1, (D) MV2, and (E) VV2 patients. Specific rounds at which every OM PrPres was detected (3rd for the MM1 and one VV2, 5th for one MV2 and one VV2, and 6th for one MV2) are shown.

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

Publisher's note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Keywords: Creutzfeldt–Jakob disease, olfactory mucosa, protein misfolding cyclic amplification, neurodegeneration, prion, peripheral biomarker

Citation: Cazzaniga FA, Bistaffa E, De Luca CMG, Portaleone SM, Catania M, Redaelli V, Tramacere I, Bufano G, Rossi M, Caroppo P, Giovagnoli AR, Tiraboschi P, Di Fede G, Eleopra R, Devigili G, Elia AE, Cilia R, Fiorini M, Bongianni M, Salzano G, Celauro L, Quarta FG, Mammana A, Legname G, Tagliavini F, Parchi P, Zanusso G, Giaccone G and Moda F (2023) Corrigendum: PMCA-based detection of prions in the olfactory mucosa of patients with sporadic Creutzfeldt–Jakob disease. Front. Aging Neurosci. 15:1073356. doi: 10.3389/fnagi.2023.1073356

Received: 18 October 2022; Accepted: 13 February 2023;
Published: 27 February 2023.

Edited and reviewed by: Rodrigo Morales, University of Texas Health Science Center at Houston, United States

Copyright © 2023 Cazzaniga, Bistaffa, De Luca, Portaleone, Catania, Redaelli, Tramacere, Bufano, Rossi, Caroppo, Giovagnoli, Tiraboschi, Di Fede, Eleopra, Devigili, Elia, Cilia, Fiorini, Bongianni, Salzano, Celauro, Quarta, Mammana, Legname, Tagliavini, Parchi, Zanusso, Giaccone and Moda. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Fabio Moda, ZmFiaW8ubW9kYUBpc3RpdHV0by1iZXN0YS5pdA==

†Present addresses: Martina Rossi, Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy
Giulia Salzano, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Research integrity at Frontiers

Man ultramarathon runner in the mountains he trains at sunset

94% of researchers rate our articles as excellent or good

Learn more about the work of our research integrity team to safeguard the quality of each article we publish.


Find out more