AUTHOR=Su Qi , Ng Wei Lun , Goh Suh Yee , Gulam Muhammad Yaaseen , Wang Lin-Fa , Tan Eng-King , Ahn Matae , Chao Yin-Xia 

TITLE=Targeting the inflammasome in Parkinson’s disease

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=14

YEAR=2022

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2022.957705

DOI=10.3389/fnagi.2022.957705

ISSN=1663-4365

ABSTRACT=<p>Parkinson’s disease (PD) is one of the most common neurodegenerative diseases in which neuroinflammation plays pivotal roles. An important mechanism of neuroinflammation is the NLRP3 inflammasome activation that has been implicated in PD pathogenesis. In this perspective, we will discuss the relationship of some key PD-associated proteins including α-synuclein and Parkin and their contribution to inflammasome activation. We will also review promising inhibitors of NLRP3 inflammasome pathway that have potential as novel PD therapeutics. Finally, we will provide a summary of current and potential <italic>in vitro</italic> and <italic>in vivo</italic> models that are available for therapeutic discovery and development.</p>