AUTHOR=Fan Xing , Xia Liye , Zhou Zheng , Qiu Yanyan , Zhao Chenhao , Yin Xiaomin , Qian Wei 

TITLE=Tau Acts in Concert With Kinase/Phosphatase Underlying Synaptic Dysfunction

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=14

YEAR=2022

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2022.908881

DOI=10.3389/fnagi.2022.908881

ISSN=1663-4365

ABSTRACT=<p>Alzheimer's disease (AD) is characterized by two pathological features: neurofibrillary tangles (NFTs), formed by microtubule-associated protein tau, and abnormal accumulation of amyloid-β (Aβ). Multiple evidence placed synaptic tau as the vital fact of AD pathology, especially at the very early stage of AD. In the present review, we discuss tau phosphorylation, which is critical for the dendritic localization of tau and synaptic plasticity. We review the related kinases and phosphatases implicated in the synaptic function of tau. We also review the synergistic effects of these kinases and phosphatases on tau-associated synaptic deficits. We aim to open a new perspective on the treatment of AD.</p>