AUTHOR=Yeh Po-Kuan , Liang Chih-Sung , Tsai Chia-Lin , Lin Yu-Kai , Lin Guan-Yu , Tsai Chia-Kuang , Tsai Ming-Chen , Liu Yi , Tai Yueh-Ming , Hung Kuo-Sheng , Yang Fu-Chi 

TITLE=Genetic Variants Associated With Subjective Cognitive Decline in Patients With Migraine

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=14

YEAR=2022

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2022.860604

DOI=10.3389/fnagi.2022.860604

ISSN=1663-4365

ABSTRACT=<p>The genetic association between subjective cognitive decline (SCD) and migraine comorbidity remains unclear. Furthermore, single nucleotide polymorphisms (SNP) associated with SCD have not been identified previously. Migraineurs were genotyped using an Affymetrix array. The correlation between different SNP variants in migraineurs with or without SCD and non-migraine controls was investigated. Migraineurs with or without SCD were further divided for the analysis of relevant SNP variants linked to migraine with aura (MA), migraine without aura (MoA), episodic migraine (EM), and chronic migraine (CM). Significant connectivity between SNPs and clinical indices in migraineurs and non-migraine controls with SCD were assessed using multivariate regression analysis. The rs144191744 SNP was found in migraineurs (<italic>p</italic> = 3.19E-08), EM (<italic>p</italic> = 1.34E-07), and MoA(<italic>p</italic> = 7.69E-07) with and without SCD. The T allele frequency for rs144191744 in TGFBR3 was 0.0054 and 0.0445 in migraineurs with and without SCD (odds ratio, 0.12), respectively. rs2352564, rs6089473 in CDH4, rs112400385 in ST18, rs4488224 and rs17111203 in ARHGAP29 SNPs were found, respectively, in non-migraineurs (<italic>p</italic> = 4.85E-06, <italic>p</italic> = 8.28E-06), MoA (<italic>p</italic> = 3.13E-07), and CM subgroups (<italic>p</italic> = 1.05E-07, 6.24E-07) with and without SCD. Rs144191744 closely relates to SCD with the all-migraine group and the EM and MoA subgroups. In conclusion, rs144191744 in TGFBR3 was significantly associated with SCD in migraineurs, especially in the EM, MoA, and female patient subgroups. Furthermore, three SNPs (rs112400385, rs4488224, and rs17111203) were associated with SCD in migraineurs but not in non-migraine controls.</p>