AUTHOR=Fu Jiajia , Huang Yan , Bao Ting , Ou Ruwei , Wei Qianqian , Chen Yongping , Yang Jing , Chen Xueping , Shang Huifang 

TITLE=Effects of Sex on the Relationship Between Apolipoprotein E Gene and Serum Lipid Profiles in Alzheimer’s Disease

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=14

YEAR=2022

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2022.844066

DOI=10.3389/fnagi.2022.844066

ISSN=1663-4365

ABSTRACT=<sec><title>Background</title><p>Sex is an important factor in studying the relationship between the <italic>APOE</italic> gene, lipid profiles, and AD. However, few studies have focused on the effect of sex on lipids in AD and normal controls with different <italic>APOE</italic> genes.</p></sec><sec><title>Materials and Methods</title><p>A total of 549 participants, including 298 AD patients and 251 body mass index (BMI)-matched healthy controls (HCs), were enrolled. Lipid profiles and <italic>APOE</italic> genes in both AD patients and HCs were determined.</p></sec><sec><title>Results</title><p>(1) TC and LDL were higher in AD patients than in HCs, only in <italic>APOE</italic>ε<italic>4</italic> carrying populations, but not in non-carrying populations. (2) TC and LDL were higher in <italic>APOE</italic>ε<italic>4</italic> allele carriers than in non-carriers, only in AD populations, but not in HCs. (3) The TC of <italic>APOE</italic>ε<italic>2</italic> carriers was lower than that of non-carriers in the male AD population, but not in the female AD population, female HCs, and male HCs. (4) The increased LDL level may increase the risk of AD in female people carrying <italic>APOE</italic>ε<italic>4</italic>.</p></sec><sec><title>Conclusion</title><p>The TC and LDL levels of <italic>APOE</italic>ε<italic>4</italic> carriers were higher than those of non-carriers, and the effect was more significant in the female AD population. The TC levels in <italic>APOE</italic>ε<italic>2</italic> carriers were lower than those in non-carriers, which was more significant in the male AD population.</p></sec>