AUTHOR=Zi Yuheng , Cai Sainan , Tan Changlian , Wang Tianyu , Shen Qin , Liu Qinru , Wang Min , Li Junli , Zhang Lin , Zhou Fan , Song Chendie , Yuan Jiaying , Liu Yujing , Liu Jun , Liao Haiyan 

TITLE=Abnormalities in the Fractional Amplitude of Low-Frequency Fluctuation and Functional Connectivity in Parkinson's Disease With Excessive Daytime Sleepiness

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=14

YEAR=2022

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2022.826175

DOI=10.3389/fnagi.2022.826175

ISSN=1663-4365

ABSTRACT=<sec><title>Background</title><p>Excessive daytime sleepiness (EDS) is one of the most important non-motor symptoms of Parkinson's disease (PD), and its neuropathologic basis is still unclear.</p></sec><sec><title>Objective</title><p>This study investigated the changes of neuronal activity in PD patients with EDS (PD-EDS) in the resting state.</p></sec><sec><title>Methods</title><p>Forty-three PD patients were recruited and divided into the PD-EDS group (<italic>n</italic> = 21) and PD-NEDS group (PD patients without excessive daytime sleepiness, <italic>n</italic> = 22) according to the Epworth sleepiness scale (ESS) scores. Patients in both groups received resting-state functional magnetic resonance imaging (rs-fMRI). The differences in fractional amplitude of low-frequency fluctuation (fALFF) between the two groups, correlations between fALFF and ESS, and functional connection (FC) between the brain regions with different fALFF values and the whole brain were analyzed.</p></sec><sec><title>Results</title><p>PD-EDS patients exhibited a decreased fALFF in the Cingulum-Ant-R, but an increased fALFF in the Putamen-R and Thalamus-L when compared with PD-NEDS patients; an increased functional connectivity between these three seed regions with different fALFF values and the right medial frontal gyrus, bilateral superior temporal gyrus, left insular, and right precuneus was observed (<italic>p</italic> &lt; 0.05), but a deceased functional connectivity between these three seed regions and the right cerebellum anterior lobe/right brainstem, right middle temporal gyrus and inferior temporal gyrus, right hippocampus/parahippocampal gyrus, right medial cingulate gyrus and bilateral middle occipital gyrus was observed (<italic>p</italic> &lt; 0.05). The value of fALFF was negatively correlated with the ESS score in the Cingulum-Ant-R, but positively correlated with the ESS score in the Putamen-R and Thalamus-L.</p></sec><sec><title>Conclusions</title><p>EDS in PD patients may be associated with changes in brain neuron activity and functional connectivity.</p></sec>