AUTHOR=Pedrini Steve , Chatterjee Pratishtha , Nakamura Akinori , Tegg Michelle , Hone Eugene , Rainey-Smith Stephanie R. , Rowe Christopher C. , Dore Vincent , Villemagne Victor L. , Ames David , Kaneko Naoki , Gardener Sam L. , Taddei Kevin , Fernando Binosha , Martins Ian , Bharadwaj Prashant , Sohrabi Hamid R. , Masters Colin L. , Brown Belinda , Martins Ralph N. 

TITLE=The Association Between Alzheimer's Disease-Related Markers and Physical Activity in Cognitively Normal Older Adults

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=14

YEAR=2022

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2022.771214

DOI=10.3389/fnagi.2022.771214

ISSN=1663-4365

ABSTRACT=<p>Previous studies have indicated that physical activity may be beneficial in reducing the risk for Alzheimer's disease (AD), although the underlying mechanisms are not fully understood. The goal of this study was to evaluate the relationship between habitual physical activity levels and brain amyloid deposition and AD-related blood biomarkers (i.e., measured using a novel high-performance mass spectrometry-based assay), in apolipoprotein E <italic>(APOE)</italic> ε4 carriers and noncarriers. We evaluated 143 cognitively normal older adults, all of whom had brain amyloid deposition assessed using positron emission tomography and had their physical activity levels measured using the International Physical Activity Questionnaire (IPAQ). We observed an inverse correlation between brain amyloidosis and plasma beta-amyloid (Aβ)<sub>1−42</sub> but found no association between brain amyloid and plasma Aβ<sub>1−40</sub> and amyloid precursor protein (APP)<sub>669−711</sub>. Additionally, higher levels of physical activity were associated with lower plasma Aβ<sub>1−40</sub>, Aβ<sub>1−42</sub>, and APP<sub>669−711</sub> levels in <italic>APOE</italic> ε4 noncarriers. The ratios of Aβ<sub>1−40</sub>/Aβ<sub>1−42</sub> and APP<sub>669−711</sub>/Aβ<sub>1−42</sub>, which have been associated with higher brain amyloidosis in previous studies, differed between <italic>APOE</italic> ε4 carriers and non-carriers. Taken together, these data indicate a complex relationship between physical activity and brain amyloid deposition and potential blood-based AD biomarkers in cognitively normal older adults. In addition, the role of <italic>APOE</italic> ε4 is still unclear, and more studies are necessary to bring further clarification.</p>