AUTHOR=Huang Liqin , Zhang Zhaohui 

TITLE=CSPα in neurodegenerative diseases

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=14

YEAR=2022

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2022.1043384

DOI=10.3389/fnagi.2022.1043384

ISSN=1663-4365

ABSTRACT=<p>Adult-onset neuronal ceroid lipofuscinosis (ANCL) is a rare neurodegenerative disease characterized by epilepsy, cognitive degeneration, and motor disorders caused by mutations in the <italic>DNAJC5</italic> gene. In addition to being associated with ANCL disease, the cysteine string proteins α (CSPα) encoded by the <italic>DNAJC5</italic> gene have been implicated in several neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease. However, the pathogenic mechanism responsible for these neurodegenerative diseases has not yet been elucidated. Therefore, this study examines the functional properties of the CSPα protein and the related mechanisms of neurodegenerative diseases.</p>