AUTHOR=Zheng Wei , Zhang Xin-Yang , Xu Rui , Huang Xiong , Zheng Ying-Jun , Huang Xing-Bing , Li Ze-Zhi , Chen Huo-Di 

TITLE=Adjunctive accelerated repetitive transcranial magnetic stimulation for older patients with depression: A systematic review

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=14

YEAR=2022

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2022.1036676

DOI=10.3389/fnagi.2022.1036676

ISSN=1663-4365

ABSTRACT=<sec><title>Objective</title><p>We performed this systemic review to investigate the therapeutic potential and safety of adjunctive accelerated repetitive transcranial magnetic stimulation (aTMS) for older patients with depression.</p></sec><sec><title>Methods</title><p>We included published randomized clinical trials (RCTs) and observational studies targeting adjunctive aTMS for older patients with depression.</p></sec><sec><title>Results</title><p>Two open-label self-controlled studies (<italic>n</italic> = 29) fulfilled the criteria for inclusion. The included studies reported significant improvements in depressive symptoms from baseline to post-aTMS (all <italic>Ps</italic> &lt; 0.05). One study reported a dropout rate of 10.5% (2/19). Mild headache was the most common adverse reaction.</p></sec><sec><title>Conclusion</title><p>The currently available evidence from two open-label self-controlled studies indicates that adjunctive aTMS is a safe and effective therapy for older patients with depression.</p></sec>