AUTHOR=Chen Man , Zhang Hang , Chu Yun-Hui , Tang Yue , Pang Xiao-Wei , Qin Chuan , Tian Dai-Shi 

TITLE=Microglial autophagy in cerebrovascular diseases

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=14

YEAR=2022

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2022.1023679

DOI=10.3389/fnagi.2022.1023679

ISSN=1663-4365

ABSTRACT=<p>Microglia are considered core regulators for monitoring homeostasis in the brain and primary responders to central nervous system (CNS) injuries. Autophagy affects the innate immune functions of microglia. Recently some evidence suggests that microglial autophagy is closely associated with brain function in both ischemic stroke and hemorrhagic stroke. Herein, we will discuss the interaction between autophagy and other biological processes in microglia under physiological and pathological conditions and highlight the interaction between microglial metabolism and autophagy. In the end, we focus on the effect of microglial autophagy in cerebrovascular diseases.</p>