AUTHOR=Gao Xiao , Kong Yawei , Li Shengxu , Dong Shiqiu , Huang Xinyu , Qi Deyu , Zhang Tao , Yan Yinkun , Chen Wei TITLE=Intermediate Effects of Body Mass Index and C-Reactive Protein on the Serum Cotinine- Leukocyte Telomere Length Association JOURNAL=Frontiers in Aging Neuroscience VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2021.827465 DOI=10.3389/fnagi.2021.827465 ISSN=1663-4365 ABSTRACT=
We aimed to examine the association between serum cotinine and leukocyte telomere length (LTL) and the intermediate effects of body mass index (BMI) and C-reactive protein (CRP) on modulating the association. This study included 4,047 adults from the 1999 to 2002 National Health and Nutrition Examination Survey. In the combined sample, after adjusting for age, race, sex, physical activity, and alcohol use, the total effect of serum cotinine on LTL was significant (standardized regression coefficient, β = −0.049,