AUTHOR=Wang Yuqing , Jiao Fengjuan , Zheng Huancheng , Kong Qingsheng , Li Ran , Zhang Xiaojie , Yan Li , Hao Yanlei , Wu Yili TITLE=Gender Difference in Associations Between Telomere Length and Risk Factors in Patients With Stroke JOURNAL=Frontiers in Aging Neuroscience VOLUME=13 YEAR=2021 URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2021.719538 DOI=10.3389/fnagi.2021.719538 ISSN=1663-4365 ABSTRACT=
Multiple risk factors of stroke are associated with telomere length shortening. Although leukocyte telomere length (LTL) is shorter in patients with stroke, the heterogeneity is high. Risk factors may be differentially associated with LTL in male and female patients contributing to the heterogeneity. However, the gender difference in associations between LTL and risk factors in stroke patients has not been investigated. In this study, we investigated the gender difference in associations between LTL and risk factors in 312 stroke patients. Real-time quantitative PCR was used to determine relative LTL, and multiple linear regression analysis was applied for association analyses. We found that LTL was negatively associated with triglyceride (TG) in all patients [β(95% CI) = −0.69 (−1.26, −0.11),