AUTHOR=Garcia-Agundez Augusto , Eickhoff Carsten TITLE=Towards Objective Quantification of Hand Tremors and Bradykinesia Using Contactless Sensors: A Systematic Review JOURNAL=Frontiers in Aging Neuroscience VOLUME=13 YEAR=2021 URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2021.716102 DOI=10.3389/fnagi.2021.716102 ISSN=1663-4365 ABSTRACT=

Assessing the progression of movement disorders such as Parkinson's Disease (PD) is key in adjusting therapeutic interventions. However, current methods are still based on subjective factors such as visual observation, resulting in significant inter-rater variability on clinical scales such as UPDRS. Recent studies show the potential of sensor-based methods to address this limitation. The goal of this systematic review is to provide an up-to-date analysis of contactless sensor-based methods to estimate hand dexterity UPDRS scores in PD patients. Two hundred and twenty-four abstracts were screened and nine articles selected for analysis. Evidence obtained in a cumulative cohort of n = 187 patients and 1, 385 samples indicates that contactless sensors, particularly the Leap Motion Controller (LMC), can be used to assess UPDRS hand motor tasks 3.4, 3.5, 3.6, 3.15, and 3.17, although accuracy varies. Early evidence shows that sensor-based methods have clinical potential and might, after refinement, complement, or serve as a support to subjective assessment procedures. Given the nature of UPDRS assessment, future studies should observe whether LMC classification error falls within inter-rater variability for clinician-measured UPDRS scores to validate its clinical utility. Conversely, variables relevant to LMC classification such as power spectral densities or movement opening and closing speeds could set the basis for the design of more objective expert systems to assess hand dexterity in PD.