AUTHOR=Oblak Adrian L. , Lin Peter B. , Kotredes Kevin P. , Pandey Ravi S. , Garceau Dylan , Williams Harriet M. , Uyar Asli , O’Rourke Rita , O’Rourke Sarah , Ingraham Cynthia , Bednarczyk Daria , Belanger Melisa , Cope Zackary A. , Little Gabriela J. , Williams Sean-Paul G. , Ash Carl , Bleckert Adam , Ragan Tim , Logsdon Benjamin A. , Mangravite Lara M. , Sukoff Rizzo Stacey J. , Territo Paul R. , Carter Gregory W. , Howell Gareth R. , Sasner Michael , Lamb Bruce T. TITLE=Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study JOURNAL=Frontiers in Aging Neuroscience VOLUME=13 YEAR=2021 URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2021.713726 DOI=10.3389/fnagi.2021.713726 ISSN=1663-4365 ABSTRACT=

The ability to investigate therapeutic interventions in animal models of neurodegenerative diseases depends on extensive characterization of the model(s) being used. There are numerous models that have been generated to study Alzheimer’s disease (AD) and the underlying pathogenesis of the disease. While transgenic models have been instrumental in understanding AD mechanisms and risk factors, they are limited in the degree of characteristics displayed in comparison with AD in humans, and the full spectrum of AD effects has yet to be recapitulated in a single mouse model. The Model Organism Development and Evaluation for Late-Onset Alzheimer’s Disease (MODEL-AD) consortium was assembled by the National Institute on Aging (NIA) to develop more robust animal models of AD with increased relevance to human disease, standardize the characterization of AD mouse models, improve preclinical testing in animals, and establish clinically relevant AD biomarkers, among other aims toward enhancing the translational value of AD models in clinical drug design and treatment development. Here we have conducted a detailed characterization of the 5XFAD mouse, including transcriptomics, electroencephalogram, in vivo imaging, biochemical characterization, and behavioral assessments. The data from this study is publicly available through the AD Knowledge Portal.