AUTHOR=Kim Hongwon , Kim Sumin , Park Sang-jun , Park Gwoncheol , Shin Hakdong , Park Myeong Soo , Kim Jongpil 

TITLE=Administration of Bifidobacterium bifidum BGN4 and Bifidobacterium longum BORI Improves Cognitive and Memory Function in the Mouse Model of Alzheimer’s Disease

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=13

YEAR=2021

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2021.709091

DOI=10.3389/fnagi.2021.709091

ISSN=1663-4365

ABSTRACT=<p>Recent evidence indicates that gut microbiota could interact with the central nervous system and affect brain function, including cognition and memory. In this study, we investigated whether <italic>Bifidobacterium bifidum</italic> BGN4 (<italic>B. bifidum</italic> BGN4)<italic> and Bifidobacterium longum</italic> BORI (<italic>B. longum</italic> BORI) alleviated the pathological features in a mouse model of Alzheimer’s disease (AD). Administration of <italic>B. bifidum</italic> BGN4 and <italic>B. longum</italic> BORI effectively suppressed amyloidosis and apoptotic processes and improved synaptic plasticity by ameliorating the neuroinflammatory response and BDNF expression. Moreover, behavioral tests indicated that <italic>B. bifidum</italic> BGN4 and <italic>B. longum</italic> BORI attenuated the cognitive and memory disability of AD mice. Taken together, the present study highlights the therapeutic potential of <italic>B. bifidum</italic> BGN4 and <italic>B. longum</italic> BORI for suppressing the pathological features of AD.</p>