AUTHOR=Sun Yahan , Xu Sen , Jiang Ming , Liu Xia , Yang Liang , Bai Zhantao , Yang Qinghu 

TITLE=Role of the Extracellular Matrix in Alzheimer’s Disease

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=13

YEAR=2021

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2021.707466

DOI=10.3389/fnagi.2021.707466

ISSN=1663-4365

ABSTRACT=<p>Alzheimer’s disease (AD) is a neurodegenerative disease with complex pathological characteristics, whose etiology and pathogenesis are still unclear. Over the past few decades, the role of the extracellular matrix (ECM) has gained importance in neurodegenerative disease. In this review, we describe the role of the ECM in AD, focusing on the aspects of synaptic transmission, amyloid-β-plaque generation and degradation, Tau-protein production, oxidative-stress response, and inflammatory response. The function of ECM in the pathological process of AD will inform future research on the etiology and pathogenesis of AD.</p>