AUTHOR=Huang Yinting , Shen Zibin , He Wenzhen 

TITLE=Identification of Gut Microbiome Signatures in Patients With Post-stroke Cognitive Impairment and Affective Disorder

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=13

YEAR=2021

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2021.706765

DOI=10.3389/fnagi.2021.706765

ISSN=1663-4365

ABSTRACT=<p>Stroke (ST), endangering human health due to its high incidence and high mortality, is a global public health problem. There is increasing evidence that there is a link between the gut microbiota (GM) and neuropsychiatric diseases. We aimed to find the GM of ST, post-ST cognitive impairment (PSCI), and post-ST affective disorder (PSTD). GM composition was analyzed, followed by GM identification. Alpha diversity estimation showed microbiota diversity in ST patients. Beta diversity analysis showed that the bacterial community structure segregated differently between different groups. At the genus level, ST patients had a significantly higher proportion of <italic>Enterococcus</italic> and lower content of <italic>Bacteroides, Escherichia-Shigella</italic>, and <italic>Megamonas</italic>. PSCI patients had a significantly higher content of <italic>Enterococcus, Bacteroides</italic>, and <italic>Escherichia-Shigella</italic> and a lower proportion of <italic>Faecalibacterium</italic> compared with patients with ST. Patients with PSTD had a significantly higher content of <italic>Bacteroides</italic> and <italic>Escherichia-Shigella</italic> and lower content of <italic>Enterococcus</italic> and <italic>Faecalibacterium. Parabacteroides</italic> and <italic>Lachnospiraceae</italic> were associated with Montreal cognitive assessment score of ST patients. Our study indicated that the characteristic GM, especially <italic>Bacteroidetes</italic>, could be used as clinical biomarkers of PSCI and PSTD.</p>