AUTHOR=Ou Ruwei , Hou Yanbing , Liu Kuncheng , Lin Junyu , Jiang Zheng , Wei Qianqian , Zhang Lingyu , Cao Bei , Zhao Bi , Song Wei , Shang Huifang 

TITLE=Progression of Fatigue in Early Parkinson’s Disease: A 3-Year Prospective Cohort Study

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=13

YEAR=2021

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2021.701906

DOI=10.3389/fnagi.2021.701906

ISSN=1663-4365

ABSTRACT=<p><bold>Objective:</bold> To explore the frequency, evolution, associated factors, and risk factors of fatigue over 3-year of prospective follow-up in a cohort of patients with early Parkinson’s disease (PD).</p><p><bold>Methods:</bold> A total of 174 PD patients in the early stage were enrolled and quantitively assessed motor and non-motor symptoms using comprehensive scales including the Fatigue Severity Scale (FSS) annually. Each subject was categorized as PD with and without fatigue based on a cut-off mean value of 4 using FSS. The generalized estimating equation (GEE) was utilized to investigate the associated factors, and the stepwise binary logistic regression model was performed to explore the predictors.</p><p><bold>Results:</bold> The frequency of fatigue was slightly changed (ranging from 35.1 to 40.4%) during the 3-year follow-up. The changed pattern of the frequency of fatigue was similar to that of anxiety. Fatigue was significantly associated with nocturnal sleep disorders (B 2.446, <italic>P</italic> &lt; 0.001), high Hamilton Anxiety Rating Scale (HAMA) score (B 1.072, <italic>P</italic> = 0.011), and high Unified PD Rating Scale (UPDRS) III score (B 1.029, <italic>P</italic> = 0.003) over time. High UPDRS III score [odds ratio (OR) 1.051, <italic>P</italic> = 0.015] at baseline increased the risk of developing fatigue after 1-year; high LEDD (OR 1.002, <italic>P</italic> = 0.037) increased the risk of developing fatigue after 2-year; and high LEDD (OR 1.003, <italic>P</italic> = 0.049) and high HAMA score (OR 1.077, <italic>P</italic> = 0.042) increased the risk of developing fatigue after 3-year.</p><p><bold>Conclusion:</bold> Our present study provided evidence of the longitudinal evolution of fatigue in patients with early PD and help clinical management of fatigue.</p>