AUTHOR=Lei Li , Yang Shuaifeng , Lu Xiaoyang , Zhang Yongfa , Li Tao 

TITLE=Research Progress on the Mechanism of Mitochondrial Autophagy in Cerebral Stroke

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=13

YEAR=2021

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2021.698601

DOI=10.3389/fnagi.2021.698601

ISSN=1663-4365

ABSTRACT=<p>Mitochondrial autophagy is an early defense and protection process that selectively clears dysfunctional or excessive mitochondria through a distinctive mechanism to maintain intracellular homeostasis. Mitochondrial dysfunction during cerebral stroke involves metabolic disbalance, oxidative stress, apoptosis, endoplasmic reticulum stress, and abnormal mitochondrial autophagy. This article reviews the research progress on the mechanism of mitochondrial autophagy in ischemic stroke to provide a theoretical basis for further research on mitochondrial autophagy and the treatment of ischemic stroke.</p>