AUTHOR=Jang Jung Yun , Han S. Duke , Yew Belinda , Blanken Anna E. , Dutt Shubir , Li Yanrong , Ho Jean K. , Gaubert Aimée , Nation Daniel A. TITLE=Resting-State Functional Connectivity Signatures of Apathy in Community-Living Older Adults JOURNAL=Frontiers in Aging Neuroscience VOLUME=13 YEAR=2021 URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2021.691710 DOI=10.3389/fnagi.2021.691710 ISSN=1663-4365 ABSTRACT=
Apathy predicts poor outcomes in older adults, and its underlying neural mechanism needs further investigation. We examined the association between symptoms of apathy and functional connectivity (FC) in older adults without stroke or dementia. Participants included 48 individuals (mean age = 70.90) living independently in the community, who underwent resting-state fMRI and completed the Apathy Evaluation Scale (AES). Seed-to-voxel analysis (cluster-level p-FDR <0.05, voxel threshold