AUTHOR=Griffiths William J. , Abdel-Khalik Jonas , Moore Sarah F. , Wijeyekoon Ruwani S. , Crick Peter J. , Yutuc Eylan , Farrell Krista , Breen David P. , Williams-Gray Caroline H. , Theofilopoulos Spyridon , Arenas Ernest , Trupp Miles , Barker Roger A. , Wang Yuqin TITLE=The Cerebrospinal Fluid Profile of Cholesterol Metabolites in Parkinson’s Disease and Their Association With Disease State and Clinical Features JOURNAL=Frontiers in Aging Neuroscience VOLUME=13 YEAR=2021 URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2021.685594 DOI=10.3389/fnagi.2021.685594 ISSN=1663-4365 ABSTRACT=

Disordered cholesterol metabolism is linked to neurodegeneration. In this study we investigated the profile of cholesterol metabolites found in the cerebrospinal fluid (CSF) of Parkinson’s disease (PD) patients. When adjustments were made for confounding variables of age and sex, 7α,(25R)26-dihydroxycholesterol and a second oxysterol 7α,x,y-trihydroxycholest-4-en-3-one (7α,x,y-triHCO), whose exact structure is unknown, were found to be significantly elevated in PD CSF. The likely location of the additional hydroxy groups on the second oxysterol are on the sterol side-chain. We found that CSF 7α-hydroxycholesterol levels correlated positively with depression in PD patients, while two presumptively identified cholestenoic acids correlated negatively with depression.