AUTHOR=She Meilin , Shang Suhang , Hu Ningwei , Chen Chen , Dang Liangjun , Gao Ling , Wei Shan , Huo Kang , Wang Jingyi , Wang Jin , Qu Qiumin 

TITLE=Blood Pressure Level Is Associated With Changes in Plasma Aβ1 –40 and Aβ1–42 Levels: A Cross-sectional Study Conducted in the Suburbs of Xi’an, China

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=13

YEAR=2021

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2021.650679

DOI=10.3389/fnagi.2021.650679

ISSN=1663-4365

ABSTRACT=<p><bold>Objectives</bold>: Amyloid-β (Aβ) deposition in the brain is the hallmark of Alzheimer’s disease (AD) pathology. Hypertension is a risk factor for AD, but the effects of hypertension on Aβ deposition are not fully determined. Considering peripheral Aβ closely relates to Aβ deposition in the brain, we investigated the relationships between blood pressure (BP) level and plasma Aβ concentrations.</p><p><bold>Methods</bold>: One-thousand and sixty-nine participants (age above 45) from a village in the suburbs of Xi’an, China were enrolled. Questionnaires and validated Chinese versions of the Mini-Mental State Examination (MMSE) were used to collect information about vascular risk factors and assess cognition function. The apolipoprotein E (ApoE) genotype was detected using PCR and sequencing. Plasma Aβ levels were measured using ELISA. The associations between BP and plasma Aβ levels were analyzed by using multivariate linear regression.</p><p><bold>Results</bold>: Plasma Aβ<sub>1–40</sub> level was higher in high BP group than that in normal BP group (53.34 ± 8.50 pg/ml vs. 51.98 ± 8.96 pg/ml, <italic>P</italic> = 0.013), in high SBP group than that in normal SBP group (53.68 ± 8.69 pg/ml vs. 51.88 ± 8.80 pg/ml, <italic>P</italic> = 0.001) and in high MABP group than that in normal MABP group (54.05 ± 8.78 pg/ml vs. 52.04 ± 8.75 pg/ml, <italic>P</italic> = 0.001). After controlling for the confounding factors, SBP (<italic>b</italic> = 0.078, <italic>P</italic> &lt; 0.001), DBP (<italic>b</italic> = 0.090, <italic>P</italic> = 0.008) and MABP (<italic>b</italic> = 0.104, <italic>P</italic> &lt; 0.001) correlated with plasma Aβ<sub>1–40</sub> level positively in ApoE ε4 non-carriers, but not ApoE ε4 carriers.</p><p><bold>Conclusions</bold>: Elevated BP levels were associated with increased plasma Aβ<sub>1–40</sub> levels in middle-aged and elderly ApoE ε4 non-carriers.</p>