AUTHOR=Yao Yi , Zhang Yonggang , Liao Xiaoyang , Yang Rong , Lei Yi , Luo Jianzhao TITLE=Potential Therapies for Cerebral Edema After Ischemic Stroke: A Mini Review JOURNAL=Frontiers in Aging Neuroscience VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2020.618819 DOI=10.3389/fnagi.2020.618819 ISSN=1663-4365 ABSTRACT=

Stroke is the leading cause of global mortality and disability. Cerebral edema and intracranial hypertension are common complications of cerebral infarction and the major causes of mortality. The formation of cerebral edema includes three stages (cytotoxic edema, ionic edema, and vasogenic edema), which involve multiple proteins and ion channels. A range of therapeutic agents that successfully target cerebral edema have been developed in animal studies, some of which have been assessed in clinical trials. Herein, we review the mechanisms of cerebral edema and the research progress of anti-edema therapies for use after ischemic stroke.