AUTHOR=Kuo Chih-Yun , Hsiao Hung-Ta , Lo Ing-Hsien , Nikolai Tomas 

TITLE=Association Between Obstructive Sleep Apnea, Its Treatment, and Alzheimer's Disease: Systematic Mini-Review

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2020.591737

DOI=10.3389/fnagi.2020.591737

ISSN=1663-4365

ABSTRACT=<p>Obstructive sleep apnea (OSA) and Alzheimer's disease (AD) are common in the elderly population. Obstructive sleep apnea that may cause significant changes in the cerebrospinal fluid β-amyloid and T-tau and/or P-tau protein levels is often identified as a risk factor for development of AD. Although the underlying mechanisms of AD are still not fully understood, a hypothesis associating OSA with AD has been already proposed. In this systematic mini-review, we first discuss the recent findings supporting the association of OSA with an increased risk of AD and then provide evidence suggesting the positive effect of OSA treatment on a reduced risk of AD.</p>