AUTHOR=Li Xiang , Tong Qiaowen , Gao Jianqing , Liu Cailong , Alzheimer’s Disease Neuroimaging Initiative , Liu Yangbo TITLE=Osteoarthritis Was Associated With a Faster Decline in Hippocampal Volumes in Cognitively Normal Older People JOURNAL=Frontiers in Aging Neuroscience VOLUME=12 YEAR=2020 URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2020.00190 DOI=10.3389/fnagi.2020.00190 ISSN=1663-4365 ABSTRACT=Objective

To examine whether osteoarthritis (OA) is associated with a change in adjusted hippocampal volumes (HpVR: hippocampal/intracranial volume × 103) over time among cognitively normal older people.

Methods

We examined the cross-sectional and longitudinal associations of OA with HpVR among individuals with normal cognition (NC) from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) study. At baseline, a total of 372 individuals with NC were included.

Results

In the cross-sectional analyses of baseline data, we did not find a significant relationship between OA and HpVR among individuals with NC. However, in the longitudinal analyses, OA was significantly associated with change in HpVR over time among individuals with NC. Specifically, compared with individuals without OA, those with OA showed a faster decline in HpVR over time when controlling for other potential confounders, including age, educational attainment, gender, and APOE4 genotype.

Conclusion

OA status was significantly associated with a change in HpVR over time among individuals with NC.