AUTHOR=Pak Victoria M. , Onen S.-Hakki , Bliwise Donald L. , Kutner Nancy G. , Russell Katherine L. , Onen Fannie 

TITLE=Sleep Disturbances in MCI and AD: Neuroinflammation as a Possible Mediating Pathway

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=12

YEAR=2020

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2020.00069

DOI=10.3389/fnagi.2020.00069

ISSN=1663-4365

ABSTRACT=<p>Mild cognitive impairment (MCI) and Alzheimer’s disease (AD) affect a high proportion of the elderly population with an increasing prevalence. Sleep disturbances are frequent in those with MCI and AD. This review summarizes existing research on sleep disturbances and neuroinflammation in MCI and AD. Although strong evidence supports various pathways linking sleep and AD pathology, the temporal direction of this central relationship is not yet known. Improved understanding of sleep disturbance and neuroinflammation in MCI and AD may aid in the identification of targets for their prevention.</p>