AUTHOR=Wang Runrun , Chen Peidong , Shen Zhiwei , Lin Guisen , Xiao Gang , Dai Zhuozhi , Zhang Bingna , Chen Yuanfeng , Lai Lihua , Zong Xiaodan , Li Yan , Tang Yanyan , Wu Renhua TITLE=Brain Amide Proton Transfer Imaging of Rat With Alzheimer’s Disease Using Saturation With Frequency Alternating RF Irradiation Method JOURNAL=Frontiers in Aging Neuroscience VOLUME=11 YEAR=2019 URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2019.00217 DOI=10.3389/fnagi.2019.00217 ISSN=1663-4365 ABSTRACT=
Amyloid-β (Aβ) deposits and some proteins play essential roles in the pathogenesis of Alzheimer’s disease (AD). Amide proton transfer (APT) imaging, as an imaging modality to detect tissue protein, has shown promising features for the diagnosis of AD disease. In this study, we chose 10 AD model rats as the experimental group and 10 sham-operated rats as the control group. All the rats underwent a Y-maze test before APT image acquisition, using saturation with frequency alternating RF irradiation (APTSAFARI) method on a 7.0 T animal MRI scanner. Compared with the control group, APT (3.5 ppm) values of brain were significantly reduced in AD models (