AUTHOR=Ryan Lee , Hay Meredith , Huentelman Matt J. , Duarte Audrey , Rundek Tatjana , Levin Bonnie , Soldan Anja , Pettigrew Corinne , Mehl Matthias R. , Barnes Carol A. 

TITLE=Precision Aging: Applying Precision Medicine to the Field of Cognitive Aging

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=11

YEAR=2019

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2019.00128

DOI=10.3389/fnagi.2019.00128

ISSN=1663-4365

ABSTRACT=<p>The current “one size fits all” approach to our cognitive aging population is not adequate to close the gap between cognitive health span and lifespan. In this review article, we present a novel model for understanding, preventing, and treating age-related cognitive impairment (ARCI) based on concepts borrowed from precision medicine. We will discuss how multiple risk factors can be classified into <italic>risk categories</italic> because of their interrelatedness in real life, the <italic>genetic variants</italic> that increase sensitivity to, or ameliorate, risk for ARCI, and the <italic>brain drivers</italic> or common mechanisms mediating brain aging. Rather than providing a definitive model of risk for ARCI and cognitive decline, the Precision Aging model is meant as a starting point to guide future research. To that end, after briefly discussing key risk categories, genetic risks, and brain drivers, we conclude with a discussion of steps that must be taken to move the field forward.</p>