AUTHOR=Boccardi Virginia , Westman Eric , Pelini Luca , Lindberg Olof , Muehlboeck J-Sebastian , Simmons Andrew , Tarducci Roberto , Floridi Piero , Chiarini Pietro , Soininen Hilkka , Kloszewska Iwona , Tsolaki Magda , Vellas Bruno , Spenger Christian , Wahlund Lars-Olof , Lovestone Simon , Mecocci Patrizia 

TITLE=Differential Associations of IL-4 With Hippocampal Subfields in Mild Cognitive Impairment and Alzheimer’s Disease

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2018.00439

DOI=10.3389/fnagi.2018.00439

ISSN=1663-4365

ABSTRACT=<p><bold>Background/Aims:</bold> We aimed to assess the association between in volumetric measures of hippocampal sub-regions – in healthy older controls (HC), subjects with mild cognitive impairment (MCI) and AD- with circulating levels of IL-4.</p><p><bold>Methods:</bold> From AddNeuroMed Project 113 HC, 101 stable MCI (sMCI), 22 converter MCI (cMCI) and 119 AD were included. Hippocampal subfield volumes were analyzed using Freesurfer 6.0.0 on high-resolution sagittal 3D-T1W MP-RAGE acquisitions. Plasmatic IL-4 was measured using ELISA assay.</p><p><bold>Results:</bold> IL-4 was found to be (a) positively associate with left subiculum volume (β = 0.226, <italic>p</italic> = 0.037) in sMCI and (b) negatively associate with left subiculum volume (β = -0.253, <italic>p</italic> = 0.011) and left presubiculum volume (β = -0.257, <italic>p</italic> = 0.011) in AD.</p><p><bold>Conclusion:</bold> Our results indicate a potential neuroprotective effect of IL-4 on the areas of the hippocampus more vulnerable to aging and neurodegeneration.</p>