AUTHOR=Li Gen , Cui Shishuang , Du Juanjuan , Liu Jin , Zhang Pingchen , Fu Yang , He Yixi , Zhou Haiyan , Ma Jianfang , Chen Shengdi 

TITLE=Association of GALC, ZNF184, IL1R2 and ELOVL7 With Parkinson’s Disease in Southern Chinese

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=10

YEAR=2018

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2018.00402

DOI=10.3389/fnagi.2018.00402

ISSN=1663-4365

ABSTRACT=<p><bold>Study Objectives:</bold> The aim of the study was to investigate the relationship between 22 single nucleotide polymorphisms (SNPs) and Parkinson’s disease (PD) in the Chinese population.</p><p><bold>Methods:</bold> A total of 250 PD patients and 240 healthy controls were recruited. The SNaPshot technique and the polymer chain reaction were used to detect 22 SNPs.</p><p><bold>Results:</bold> rs8005172 of <italic>GALC</italic>, rs9468199 of <italic>ZNF184</italic> and rs34043159 of <italic>IL1R2</italic>, were associated with PD (rs8005172: <italic>p</italic> = 0.009, OR = 0.69, allele model, <italic>p</italic> = 0.010, additive model, <italic>p</italic> = 0.015, OR = 2.17, dominant model; <italic>p</italic> = 0.020, OR = 2.11, dominant model after adjustment; <italic>p</italic> = 0.036, OR = 1.47, recessive model after adjustment; rs9468199: <italic>p</italic> = 0.008, OR = 1.52, allele model, <italic>p</italic> = 0.008, additive model, <italic>p</italic> = 0.007, OR = 0.22, recessive model, <italic>p</italic> = 0.005, OR = 0.20, recessive model after adjustment; rs34043159: <italic>p</italic> = 0.034, OR = 1.31, allele model, <italic>p</italic> = 0.036, additive model).</p><p><bold>Conclusion:</bold> Our study revealed that <italic>GALC</italic>, <italic>ZNF184</italic>, and <italic>IL1R2</italic> were associated with PD in the southern Chinese population. <italic>GALC</italic> was also associated with LOPD. <italic>ELOVL7</italic> and <italic>ZNF184</italic> were associated with EOPD. In addition, trends of association to PD, between <italic>SATB1</italic>, <italic>NMD3</italic>, and <italic>FGF20</italic>, were also found.</p><p><bold>Statement of Significance:</bold> Genetic play an important role in the pathogenesis factors of Parkinson’s disease (PD). We found that <italic>GALC</italic>, <italic>ZNF184</italic>, and <italic>IL1R2</italic> were associated with PD. <italic>GALC</italic> was also associated with late onset of PD, while <italic>ELOVL7</italic> and <italic>ZNF184</italic> were associated with early onset PD. This study is the first to find an association between <italic>GALC</italic>, <italic>ZNF184</italic>, and rs2280104 with PD.</p>