AUTHOR=Riello Marianna , Faria Andreia V. , Ficek Bronte , Webster Kimberly , Onyike Chiadi U. , Desmond John , Frangakis Constantine , Tsapkini Kyrana 

TITLE=The Role of Language Severity and Education in Explaining Performance on Object and Action Naming in Primary Progressive Aphasia

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=10

YEAR=2018

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2018.00346

DOI=10.3389/fnagi.2018.00346

ISSN=1663-4365

ABSTRACT=<p>Despite the common assumption that atrophy in a certain brain area would compromise the function that it subserves, this is not always the case, especially in complex clinical syndromes such as primary progressive aphasia (PPA). Clinical and demographic information may contribute to PPA phenotypes and explain the manifested impairments better than atrophy. In the present study, we asked how much variance of the object and action naming impairments observed in PPA may be attributed to atrophy in the language network alone vs. additional clinical and demographic factors including language severity and education. Thirty-nine participants with PPA underwent magnetic resonance imaging (MRI) for volumetric analysis and a complete neuropsychological examination, including standardized tests of object and action naming. We used stepwise regression models to compare atrophy (<italic>volumetric</italic> model) to clinical/demographic variables (<italic>clinical-demographic</italic> model) for naming objects and actions. The <italic>clinical-demographic</italic> model was the best-fit model that explained the largest amount of variance in both object and action naming. Brain volume measurements alone explained little variance in both object and action naming. Clinical factors, particularly language severity, and demographic factors, particularly education, need to be considered in conjunction with brain volumes in PPA. The present study emphasizes the complexity of PPA as a syndrome and provides an example of how volumetric, clinical and demographic factors may interact in determining naming performance/deterioration.</p>