AUTHOR=Leeuwis Anna E. , Smith Lorna A. , Melbourne Andrew , Hughes Alun D. , Richards Marcus , Prins Niels D. , Sokolska Magdalena , Atkinson David , Tillin Therese , Jäger Hans R. , Chaturvedi Nish , Flier Wiesje M. van der , Barkhof Frederik
TITLE=Cerebral Blood Flow and Cognitive Functioning in a Community-Based, Multi-Ethnic Cohort: The SABRE Study
JOURNAL=Frontiers in Aging Neuroscience
VOLUME=10
YEAR=2018
URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2018.00279
DOI=10.3389/fnagi.2018.00279
ISSN=1663-4365
ABSTRACT=Introduction: Lower cerebral blood flow (CBF) is associated with cardiovascular disease and vascular risk factors, and is increasingly acknowledged as an important contributor to cognitive decline and dementia. In this cross-sectional study, we examined the association between CBF and cognitive functioning in a community-based, multi-ethnic cohort.
Methods: From the SABRE (Southall and Brent Revisited) study, we included 214 European, 151 South Asian and 87 African Caribbean participants (71 ± 5 years; 39%F). We used 3T pseudo-continuous arterial spin labeling to estimate whole-brain, hematocrit corrected CBF. We measured global cognition and three cognitive domains (memory, executive functioning/attention and language) with a neuropsychological test battery. Associations were investigated using linear regression analyses, adjusted for demographic variables, vascular risk factors and MRI measures.
Results: Across groups, we found an association between higher CBF and better performance on executive functioning/attention (standardized ß [stß] = 0.11, p < 0.05). Stratification for ethnicity showed associations between higher CBF and better performance on memory and executive functioning/attention in the white European group (stß = 0.14; p < 0.05 and stß = 0.18; p < 0.01 respectively), associations were weaker in the South Asian and African Caribbean groups.
Conclusions: In a multi-ethnic community-based cohort we showed modest associations between CBF and cognitive functioning. In particular, we found an association between higher CBF and better performance on executive functioning/attention and memory in the white European group. The observations are consistent with the proposed role of cerebral hemodynamics in cognitive decline.