AUTHOR=Fan Ling-Yun , Tzen Kai-Yuan , Chen Ya-Fang , Chen Ta-Fu , Lai Ya-Mei , Yen Ruoh-Fang , Huang Ya-Yao , Shiue Chyng-Yann , Yang Shieh-Yueh , Chiu Ming-Jang 

TITLE=The Relation Between Brain Amyloid Deposition, Cortical Atrophy, and Plasma Biomarkers in Amnesic Mild Cognitive Impairment and Alzheimer’s Disease

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=10

YEAR=2018

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2018.00175

DOI=10.3389/fnagi.2018.00175

ISSN=1663-4365

ABSTRACT=<p><bold>Background:</bold> Neuritic plaques and neurofibrillary tangles are the pathological hallmarks of Alzheimer’s disease (AD), while the role of brain amyloid deposition in the clinical manifestation or brain atrophy remains unresolved. We aimed to explore the relation between brain amyloid deposition, cortical thickness, and plasma biomarkers.</p><p><bold>Methods:</bold> We used <sup>11</sup>C-Pittsburgh compound B-positron emission tomography to assay brain amyloid deposition, magnetic resonance imaging to estimate cortical thickness, and an immunomagnetic reduction assay to measure plasma biomarkers. We recruited 39 controls, 25 subjects with amnesic mild cognitive impairment (aMCI), and 16 subjects with AD. PiB positivity (PiB+) was defined by the upper limit of the 95% confidence interval of the mean cortical SUVR from six predefined regions (1.0511 in this study).</p><p><bold>Results:</bold> All plasma biomarkers showed significant between-group differences. The plasma Aβ<sub>40</sub> level was positively correlated with the mean cortical thickness of both the PiB+ and PiB- subjects. The plasma Aβ<sub>40</sub> level of the subjects who were PiB+ was negatively correlated with brain amyloid deposition. In addition, the plasma tau level was negatively correlated with cortical thickness in both the PiB+ and PiB- subjects. Moreover, cortical thickness was negatively correlated with brain amyloid deposition in the PiB+ subjects. In addition, the cut-off point of plasma tau for differentiating between controls and AD was higher in the PiB- group than in the PiB+ group (37.5 versus 25.6 pg/ml, respectively). Lastly, ApoE4 increased the PiB+ rate in the aMCI and control groups.</p><p><bold>Conclusion:</bold> The contributions of brain amyloid deposition to cortical atrophy are spatially distinct. Plasma Aβ<sub>40</sub> might be a protective indicator of less brain amyloid deposition and cortical atrophy. It takes more tau pathology to reach the same level of cognitive decline in subjects without brain amyloid deposition, and ApoE4 plays an early role in amyloid pathogenesis.</p>