AUTHOR=Teixeira Francisco B. , Saito Miki T. , Matheus Filipe C. , Prediger Rui D. , Yamada Elizabeth S. , Maia Cristiane S. F. , Lima Rafael R. 

TITLE=Periodontitis and Alzheimer’s Disease: A Possible Comorbidity between Oral Chronic Inflammatory Condition and Neuroinflammation

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=9

YEAR=2017

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2017.00327

DOI=10.3389/fnagi.2017.00327

ISSN=1663-4365

ABSTRACT=<p>Periodontitis is an oral chronic infection/inflammatory condition, identified as a source of mediators of inflammation into the blood circulation, which may contribute to exacerbate several diseases. There is increasing evidence that inflammation plays a key role in the pathophysiology of Alzheimer’s disease (AD). Although inflammation is present in both diseases, the exact mechanisms and crosslinks between periodontitis and AD are poorly understood. Therefore, this article aims to review possible comorbidity between periodontitis and AD. Here, the authors discuss the inflammatory aspects of periodontitis, how this oral condition produces a systemic inflammation and, finally, the contribution of this systemic inflammation for worsening neuroinflammation in the progression of AD.</p>