AUTHOR=Franke Katja , Clarke Geoffrey D. , Dahnke Robert , Gaser Christian , Kuo Anderson H. , Li Cun , Schwab Matthias , Nathanielsz Peter W. TITLE=Premature Brain Aging in Baboons Resulting from Moderate Fetal Undernutrition JOURNAL=Frontiers in Aging Neuroscience VOLUME=Volume 9 - 2017 YEAR=2017 URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2017.00092 DOI=10.3389/fnagi.2017.00092 ISSN=1663-4365 ABSTRACT=
Contrary to the known benefits from a moderate dietary reduction during adulthood on life span and health, maternal nutrient reduction during pregnancy is supposed to affect the developing brain, probably resulting in impaired brain structure and function throughout life. Decreased fetal nutrition delivery is widespread in both developing and developed countries, caused by poverty and natural disasters, but also due to maternal dieting, teenage pregnancy, pregnancy in women over 35 years of age, placental insufficiency, or multiples. Compromised development of fetal cerebral structures was already shown in our baboon model of moderate maternal nutrient reduction. The present study was designed to follow-up and evaluate the effects of moderate maternal nutrient reduction on individual brain aging in the baboon during young adulthood (4–7 years; human equivalent 14–24 years), applying a novel, non-invasive neuroimaging aging biomarker. The study reveals premature brain aging of +2.7 years (