AUTHOR=Zheng Qiuyang , Huang Timothy , Zhang Lishan , Zhou Ying , Luo Hong , Xu Huaxi , Wang Xin 

TITLE=Dysregulation of Ubiquitin-Proteasome System in Neurodegenerative Diseases

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=8

YEAR=2016

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2016.00303

DOI=10.3389/fnagi.2016.00303

ISSN=1663-4365

ABSTRACT=<p>The ubiquitin-proteasome system (UPS) is one of the major protein degradation pathways, where abnormal UPS function has been observed in cancer and neurological diseases. Many neurodegenerative diseases share a common pathological feature, namely intracellular ubiquitin-positive inclusions formed by aggregate-prone neurotoxic proteins. This suggests that dysfunction of the UPS in neurodegenerative diseases contributes to the accumulation of neurotoxic proteins and to instigate neurodegeneration. Here, we review recent findings describing various aspects of UPS dysregulation in neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease.</p>