AUTHOR=Cozac Vitalii V. , Chaturvedi Menorca , Hatz Florian , Meyer Antonia , Fuhr Peter , Gschwandtner Ute 

TITLE=Increase of EEG Spectral Theta Power Indicates Higher Risk of the Development of Severe Cognitive Decline in Parkinson’s Disease after 3 Years

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=8

YEAR=2016

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2016.00284

DOI=10.3389/fnagi.2016.00284

ISSN=1663-4365

ABSTRACT=<p><bold>Objective:</bold> We investigated quantitative electroencephalography (qEEG) and clinical parameters as potential risk factors of severe cognitive decline in Parkinson’s disease.</p><p><bold>Methods:</bold> We prospectively investigated 37 patients with Parkinson’s disease at baseline and follow-up (after 3 years). Patients had no severe cognitive impairment at baseline. We used a summary score of cognitive tests as the outcome at follow-up. At baseline we assessed motor, cognitive, and psychiatric factors; qEEG variables [global relative median power (GRMP) spectra] were obtained by a fully automated processing of high-resolution EEG (256-channels). We used linear regression models with calculation of the explained variance to evaluate the relation of baseline parameters with cognitive deterioration.</p><p><bold>Results:</bold> The following baseline parameters significantly predicted severe cognitive decline: GRMP theta (4–8 Hz), cognitive task performance in executive functions and working memory.</p><p><bold>Conclusions:</bold> Combination of neurocognitive tests and qEEG improves identification of patients with higher risk of cognitive decline in PD.</p>