AUTHOR=Romero Alejandro , Ramos Eva , Patiño Paloma , Oset-Gasque Maria J. , López-Muñoz Francisco , Marco-Contelles José , Ayuso María I. , Alcázar Alberto 

TITLE=Melatonin and Nitrones As Potential Therapeutic Agents for Stroke

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=8

YEAR=2016

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2016.00281

DOI=10.3389/fnagi.2016.00281

ISSN=1663-4365

ABSTRACT=<p>Stroke is a disease of aging affecting millions of people worldwide, and recombinant tissue-type plasminogen activator (r-tPA) is the only treatment approved. However, r-tPA has a low therapeutic window and secondary effects which limit its beneficial outcome, urging thus the search for new more efficient therapies. Among them, neuroprotection based on melatonin or nitrones, as free radical traps, have arisen as drug candidates due to their strong antioxidant power. In this <italic>Perspective</italic> article, an update on the specific results of the melatonin and several new nitrones are presented.</p>