AUTHOR=Mondini Sara , Madella Ileana , Zangrossi Andrea , Bigolin Angela , Tomasi Claudia , Michieletto Marta , Villani Daniele , Di Giovanni Giuseppina , Mapelli Daniela 

TITLE=Cognitive Reserve in Dementia: Implications for Cognitive Training

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=8

YEAR=2016

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2016.00084

DOI=10.3389/fnagi.2016.00084

ISSN=1663-4365

ABSTRACT=<p>Cognitive reserve (CR) is a potential mechanism to cope with brain damage. The aim of this study was to evaluate the effect of CR on a cognitive training (CT) in a group of patients with dementia. Eighty six participants with mild to moderate dementia were identified by their level of CR quantified by the CR Index questionnaire (CRIq) and underwent a cycle of CT. A global measure of cognition mini mental state examination (MMSE) was obtained before (T0) and after (T1) the training. Multiple linear regression analyses highlighted CR as a significant factor able to predict changes in cognitive performance after the CT. In particular, patients with lower CR benefited from a CT program more than those with high CR. These data show that CR can modulate the outcome of a CT program and that it should be considered as a predictive factor of neuropsychological rehabilitation training efficacy in people with dementia.</p>