AUTHOR=Herrera María I. , Kölliker-Frers Rodolfo , Barreto George , Blanco Eduardo , Capani Francisco 

TITLE=Glial Modulation by N-acylethanolamides in Brain Injury and Neurodegeneration

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=8

YEAR=2016

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2016.00081

DOI=10.3389/fnagi.2016.00081

ISSN=1663-4365

ABSTRACT=<p>Neuroinflammation involves the activation of glial cells and represents a key element in normal aging and pathophysiology of brain damage. <italic>N</italic>-acylethanolamides (NAEs), naturally occurring amides, are known for their pro-homeostatic effects. An increase in NAEs has been reported <italic>in vivo</italic> and <italic>in vitro</italic> in the aging brain and in brain injury. Treatment with NAEs may promote neuroprotection and exert anti-inflammatory actions via PPARα activation and/or by counteracting gliosis. This review aims to provide an overview of endogenous and exogenous properties of NAEs in neuroinflammation and to discuss their interaction with glial cells.</p>