AUTHOR=Bridi Jessika Cristina , Barros Alexandre Guimarães de Almeida , Sampaio Letícia Reis , Ferreira Júlia Castro Damásio , Antunes Soares Felix Alexandre , Romano-Silva Marco Aurélio 

TITLE=Lifespan Extension Induced by Caffeine in Caenorhabditis elegans is Partially Dependent on Adenosine Signaling

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=7

YEAR=2015

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2015.00220

DOI=10.3389/fnagi.2015.00220

ISSN=1663-4365

ABSTRACT=<p>Caffeine is a widely used psychoactive substance. Studies have shown that caffeine may play a protective role in aging-associated disorders. However, the mechanisms by which caffeine modulates aging are not yet clear. In this study, we have shown that caffeine increases <italic>Caenorhabditis elegans</italic> lifespan, delays its larval development, reduces reproduction and body length. These phenotypes were partly reversed by worm’s exposure to adenosine, which suggest a putative common target. Moreover, they were dependent on a functional insulin/IGF-1-like pathway. Our results may shed light on new genetic determinants of aging.</p>