AUTHOR=Breton Yannick-André , Seeland Kelsey D. , Redish A. David TITLE=Aging impairs deliberation and behavioral flexibility in inter-temporal choice JOURNAL=Frontiers in Aging Neuroscience VOLUME=7 YEAR=2015 URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2015.00041 DOI=10.3389/fnagi.2015.00041 ISSN=1663-4365 ABSTRACT=
Inter-temporal choice depends on multiple, interacting systems, some of which may be compromised with age. Some of these systems may be responsible for ongoing trial-by-trial choice strategies. Some may represent the consequences of action. Some may be necessary for the coupling between anticipated consequences and strategies currently in use, flexibly guiding behavior. When faced with a difficult decision, rats will orient back and forth, a behavior termed “vicarious trial and error” (VTE). Recent experiments have linked the occurrence of VTE to hippocampal search processes and behavioral flexibility. We tested 5 month (