AUTHOR=Sakuma Kunihiro , Aoi Wataru , Yamaguchi Akihiko 

TITLE=The Intriguing Regulators of Muscle Mass in Sarcopenia and Muscular Dystrophy

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=6

YEAR=2014

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2014.00230

DOI=10.3389/fnagi.2014.00230

ISSN=1663-4365

ABSTRACT=<p>Recent advances in our understanding of the biology of muscle have led to new interest in the pharmacological treatment of muscle wasting. Loss of muscle mass and increased intramuscular fibrosis occur in both sarcopenia and muscular dystrophy. Several regulators (mammalian target of rapamycin, serum response factor, atrogin-1, myostatin, etc.) seem to modulate protein synthesis and degradation or transcription of muscle-specific genes during both sarcopenia and muscular dystrophy. This review provides an overview of the adaptive changes in several regulators of muscle mass in both sarcopenia and muscular dystrophy.</p>