AUTHOR=Sharma Kaushal , Sharma Neel Kamal , Anand Akshay TITLE=Why AMD is a disease of ageing and not of development: mechanisms and insights JOURNAL=Frontiers in Aging Neuroscience VOLUME=Volume 6 - 2014 YEAR=2014 URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2014.00151 DOI=10.3389/fnagi.2014.00151 ISSN=1663-4365 ABSTRACT=Age related macular degeneration (AMD) is retinal degenerative disorder which starts with the progression of age. Metabolism plays important role in initiation of ageing related diseases. The cholesterol metabolism components and their oxidized products like 7-ketocholesterol have been shown impact on RPE cells degeneration. These molecules can initiate the mitochondrial apoptotic process and also influenced the complements factors and expression of angiogenic proteins like VEGF etc. In this review we have suggested that AMD is ageing disorder not developmental which has been substantiated with disrupted cholesterol metabolism as described in several age related degenerative diseases.